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Cardiometabolism and Venous Diseases

Where do we focus our efforts?

Cardiovascular, metabolic, and venous diseases (CMVD) are a major public health issue. Many patients face not just one disease, but multiple CMVD-related conditions. And even though treatments are available, far too many patients struggle to follow their prescribed treatment plans to the letter.

  • Cardiovascular diseases (primarily hypertension, coronary artery disease, heart failure) and elevated cholesterol levels are on the rise worldwide. To address this public health challenge, we have worked alongside patients and health care professionals on a daily basis for over 70 years.
Did you know?

Cardiovascular diseases and associated complications are the leading cause of death worldwide, accounting for 19.8 million deaths in 2022, or 32% of global mortality rates1.

No. 1

pharmaceutical group worldwide in hypertension2

No. 6

pharmaceutical group worldwide in cardiology2

  • Type 2 diabetes accounts for more than 95% of all diabetes cases worldwide3. It is a complex and progressive disease that constitutes a serious public health burden. We have spearheaded a number of global initiatives aimed at improving patient care and quality of life.
  • Chronic venous disease and hemorrhoidal disease affect a large number of people and manifest in different ways. And yet, these conditions have a common underlying cause: weakened vein walls and valves, combined with inflammation, which leads to venous insufficiency. For this reason, it is important to treat conditions as soon as symptoms appear and slow their progression toward more advanced stages and/or recurrence. Our work is focused on gaining a better understanding of venous insufficiency and treating related symptoms.

In R&D, our teams endeavor daily to advance the development of medicines in areas where patient needs have not yet been adequately addressed. Our focus is on transformative medicine projects.

Our efforts in cardiometabolism are concentrated on treatment adherence and managing cardiovascular risk factors such as hypertension, diabetes, and dyslipidemia. In this way, we can leverage our existing medicines and expertise in incremental innovation. In particular, we are developing Single Pill Combinations (SPCs), which combine several fixed-dose medicines in a single tablet, designed to simplify daily medication intake. SPCs promote better compliance with prescribed treatment plans so that risk factors can be controlled, thereby significantly transforming how patients are cared for by medical professionals.

13

As of September 2025, we have 13 clinical development projects in our cardiometabolism & venous diseases pipeline

(Single Pill Combinations and New Formulations)

Learn more about our development pipeline

Tackling treatment adherence head-on

Adherence to chronic treatment plans has become a key issue in the health care sector. Despite the availability of a wide range of therapeutic solutions, non-compliance is very common and can have a significant impact on patient health. At Servier, we take this concern very seriously. We firmly believe that treatment adherence is key to treating patients and improving their care, and that this constitutes an unmet medical need4.

Did you know?

On March 27, 2025, the World Heart Federation, along with Servier and 14 partner institutions, launched the first World Adherence Day.

We place particular emphasis on three key areas:

  • Single pill combinations (SPCs) combine several molecules in a single tablet to simplify treatment and make it easier for patients to take their medication every day. Learn more about single pill combinations.
  • Beyond the pill digital innovation uses digital applications as “digital companions” to support patient health.
  • Therapeutic information raises awareness and educates patients and health care professionals through close collaboration with international experts, scientific societies, and patient organizations. The aim is to empower patients to take an active role in their treatment by helping them to better understand their disease and treatment options.Find out more about training for health care professionals.

As a member of the Innovative Medicines Initiative (IMI) consortium, we are participating in a project designed to identify typical patient behaviors in order to propose tailored solutions that improve treatment adherence: “BEAMER,” for Behavioral and Adherence Model for improving quality, health outcomes and cost-Effectiveness of healthcaRe. This project was launched in 2021 and will run for five years.

The goal is to identify patient behavior patterns so that appropriate solutions can be provided to improve compliance with treatment.

Voices in support of therapeutic adherence: Mobilizing, bearing witness, and innovating

Read the article in our “Insights” magazine

Explore our in-depth articles

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Understanding Hypertension

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Understanding Angina Pectoris

In-depth articles

Heart failure: When the heart can no longer keep up

In-depth articles

Venous disease: When the circulatory system is affected

In-depth articles

Understanding Type 2 Diabetes

Type 2 diabetes: A brochure that helps improve communication between patients and doctors

Co-designed with patient representatives from different countries, the “Patient-Doctor: Speaking the Same Language” brochure provides type 2 diabetes patients around the world with information and advice on how to better communicate with their health care provider.

Cover of the "Patient-Doctor: Let's speak the same language" brochure

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[1] WHO, July 2025 / https://www.who.int/fr/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
[2] IQVIA, Analytics Link / World 82 countries – MAT Q2-2025
[3] WHO, November 2024 / https://www.who.int/fr/news-room/fact-sheets/detail/diabetes
[4] UMN Cardiovascular blog, efpia.eu